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ACUTE INFLAMMATION AND TISSUE MAST CELLS IN ADRENALECTOMIZED RATS WITH CUTANEOUS MUCORMYCOSIS

S H PAPLANUS, W H SHELDON

    The Journal of Experimental Medicine
    |August 1, 1963
    PubMed

    Insights

    Adrenalectomy delays inflammation resolution and mast cell recovery in rats with fungal infections. However, adrenal absence does not worsen fungal growth or infection spread, indicating inflammation effectiveness is similar in normal and adrenalectomized rats.

    Area of Science:

    • Immunology
    • Endocrinology
    • Mycology

    Background:

    • Adrenal tissues play a role in regulating inflammatory responses.
    • Mast cells are crucial in mediating inflammation.
    • Rhizopus oryzae is a fungal pathogen that can cause cutaneous infections.

    Purpose of the Study:

    • To investigate the impact of adrenal tissue absence on inflammatory reactions.
    • To examine the role of tissue mast cells in the inflammatory process during Rhizopus oryzae infection.
    • To determine if adrenalectomy affects fungal proliferation or infection spread.

    Main Methods:

    • Histological examination of cutaneous Rhizopus oryzae infection in rats.
    • Comparison between adrenalectomized and normal rats.
    • Observation of mast cell degranulation and regranulation.
    • Assessment of cellular phases of inflammation (exudative and proliferative).

    Main Results:

    • Mast cell degranulation correlated with inflammation onset, and regranulation with subsidence.
    • Adrenalectomized rats showed delayed mast cell regranulation and delayed termination of the exudative inflammatory phase.
    • Increased eosinophils were observed in adrenalectomized rat lesions.
    • Inflammatory proliferative processes were delayed but otherwise normal, with increased collagen deposition.
    • Adrenal secretions did not influence fungal proliferation or infection spread.

    Conclusions:

    • Adrenalectomy delays the resolution of inflammation and mast cell recovery.
    • The absence of adrenal secretions does not exacerbate Rhizopus oryzae infection.
    • Inflammation effectiveness is comparable between normal and adrenalectomized rats in this model.
    Keywords:
    ADRENALECTOMYEXPERIMENTAL LAB STUDYINFLAMMATIONMAST CELLSMUCORMYCOSISPATHOLOGYRATSRHIZOPUS

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