Related Experiment Video

Updated: Aug 5, 2026

Correlative Light and Electron Microscopy to Study Microglial Interactions with β-Amyloid Plaques
10:52

Correlative Light and Electron Microscopy to Study Microglial Interactions with β-Amyloid Plaques

Published on: June 1, 2016

Amyloidoma of the CNS. I. Clinical and pathologic study

M Cohen1, D Lanska, U Roessmann

  • 1Division of Neuropathology, Case Western Reserve University, Cleveland, OH 44106.

Neurology
|October 1, 1992
PubMed

Insights

A rare case of multifocal amyloidomas caused headaches, seizures, and dementia in a 32-year-old man. Microglial cells processed plasma-cell-derived amyloidogenic protein, leading to these brain lesions.

Area of Science:

  • Neurology
  • Neuropathology
  • Immunohistochemistry

Background:

  • Amyloidomas are rare intracranial masses composed of amyloid.
  • Their pathogenesis is not fully understood, particularly in multifocal white matter presentations.

Observation:

  • A 32-year-old male presented with a 4-year history of progressive headaches, seizures, and cognitive decline.
  • Brain imaging revealed multifocal lesions within the white matter.

Findings:

  • Histopathological examination identified amyloidomas as the cause of the neurological symptoms.
  • Immunohistochemical and electron microscopic analyses indicated that microglial cells were involved in processing plasma-cell-derived amyloidogenic proteins.

Implications:

  • This case highlights a novel mechanism for amyloidoma formation involving microglial-mediated processing of amyloidogenic proteins.
  • Understanding this pathway may offer new therapeutic targets for amyloid-related neurological disorders.

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