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Updated: Jul 18, 2026

Induction of Graft-versus-host Disease and In Vivo T Cell Monitoring Using an MHC-matched Murine Model
Published on: August 29, 2012
RADIATION-INDUCED MOUSE LEUKEMIA: CONSISTENT OCCURRENCE OF AN EXTRA AND A MARKER CHROMOSOME
Abstract:
Granulocytic leukemia, induced in the primary mouse by x-irradiation, was serially transmitted to RF/Up mice. An extra chromosome, as well as a morphologicaly unusual chromosome, was found in the bone marrow cells of all the leukemic mice that had been injected previously either with leukemic spleen cells or with cell-free ultracentrifugates. This suggests that the changes in the chromosomes are caused by a virus.
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