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Related Experiment Videos

H-2 mutation affecting immune response to Thy-1.1 antigen.

M Zaleski, J Klein

    The Journal of Experimental Medicine
    |June 1, 1977
    PubMed
    Summary
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    Researchers identified immune response genes controlling Thy-1.1 antigen. These genes, Ir-Thy-1A and Ir-Thy-1B, are linked to the mouse major histocompatibility complex (H-2).

    Area of Science:

    • Immunogenetics
    • Molecular Biology
    • Mouse Models

    Background:

    • The Thy-1 locus on mouse chromosome 9 determines a shared antigen in thymus, lymphocytes, and brain.
    • Two alleles, Thy-1.1 and Thy-1.2, exist, defining different mouse strains.
    • Immune responses to Thy-1.1 can be measured serologically or via plaque-forming cells (PFC).

    Purpose of the Study:

    • To investigate the genetic control of immune responses to the Thy-1.1 antigen.
    • To further map the locations of immune response (Ir) genes linked to the H-2 complex.

    Main Methods:

    • Injection of AKR thymocytes into mice with the Thy-1.1 antigen.
    • Measurement of serum antibody levels and spleen plaque-forming cells (PFC).
    • Genetic analysis using H-2 recombinant strains and an H-2 mutant (CBA-H-2(ka)).

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    Main Results:

    • Three genes (Ir-Thy-1A, Ir-Thy-1B, and Ir-5) control the PFC response to Thy-1.1.
    • Ir-Thy-1A and Ir-Thy-1B are closely linked to the mouse major histocompatibility complex (H-2).
    • Evidence suggests one Ir-Thy-1 locus maps to the H-2K region, potentially identical to the H-2K locus.

    Conclusions:

    • The genetic mapping of immune response loci provides insights into immune regulation.
    • The H-2K region is implicated in the immune response to the Thy-1.1 antigen.