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Related Experiment Videos

Fluvoxamine treatment for chronic PTSD: a pilot study.

M De Boer1, W Op den Velde, P J Falger

  • 1Department of Psychiatry, St. Lucas Hospital, Amsterdam, The Netherlands.

Psychotherapy and Psychosomatics
|January 1, 1992
PubMed
Summary
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Fluvoxamine, a selective serotonin reuptake inhibitor, showed modest but significant improvements in chronic posttraumatic stress disorder (PTSD) symptoms for World War II veterans. The treatment offered some relief for insomnia, anxiety, and exhaustion in this long-suffering group.

Area of Science:

  • Psychiatry
  • Pharmacology
  • Military Medicine

Background:

  • Chronic posttraumatic stress disorder (PTSD) in elderly veterans presents significant challenges due to long-standing, intractable symptoms.
  • World War II Resistance veterans represent a unique cohort with decades of enduring traumatic war-related complaints.

Purpose of the Study:

  • To evaluate the efficacy of fluvoxamine in alleviating chronic PTSD symptoms in a cohort of Dutch World War II Resistance veterans.
  • To assess the impact of fluvoxamine on associated symptoms such as depression, anxiety, insomnia, and vital exhaustion.

Main Methods:

  • An open-ended, outpatient pilot study involving 24 Dutch World War II Resistance veterans diagnosed with chronic PTSD.
  • A 12-week treatment period utilizing fluvoxamine (Fevarin), a selective serotonin reuptake inhibitor.

Related Experiment Videos

  • Assessment through clinical examination and questionnaires measuring PTSD, depression, sleep disturbances, anxiety, and vital exhaustion.

    • Main Results:

    • A significant number of participants showed improvement in PTSD symptomatology, anxiety, and vital exhaustion.
    • Quantitative improvements were modest at the study's conclusion.
    • Specific symptom relief was noted for insomnia, nightmares, anxiety, intrusive recollections, guilt feelings, and tiredness.

    Conclusions:

    • Fluvoxamine may offer a degree of alleviation for chronic PTSD symptoms in long-term sufferers.
    • The study suggests potential benefits of selective serotonin reuptake inhibitors for intractable posttraumatic complaints.
    • Further research is warranted to optimize treatment strategies for chronic PTSD in veteran populations.