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Updated: Aug 11, 2026

Characterization of Thymic Settling Progenitors in the Mouse Embryo Using In Vivo and In Vitro Assays
08:56

Characterization of Thymic Settling Progenitors in the Mouse Embryo Using In Vivo and In Vitro Assays

Published on: June 9, 2015

HUMORAL THYMIC FACTOR IN MICE: FURTHER EVIDENCE

L W LAW, N TRAININ, R H LEVEY

    Science (New York, N.Y.)
    |March 6, 1964
    PubMed

    Mice of the C3H and DBA strains thymectomized at birth showed a consistent and striking suppression of antibody production (hemolysin response) to sheep erythrocytes. When cell-tight Millipore diffusion chambers containing syngeneic thymic tissue were implanted intraperitoneally, the capacity of these neonatally thymectomized mice to respond to this antigen was restored. The pattern of response and the mean titer were similar to the pattern and mean titer observed in neonatally thymectomized mice bearing subcutaneous grafts of syngeneic thymic tissue. These data are consistent with the concept that thymic tissue within the chamber produced a specific diffusible factor that enabled the thymectomized animal to establish immunologic competence.

    Keywords:
    ANIMALS, NEWBORNANTIBODY FORMATIONANTIGEN-ANTIBODY REACTIONSEXPERIMENTAL LAB STUDYHEMOLYSISMICEPHYSIOLOGYSURGERY, OPERATIVETHYMUS GLAND

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