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THE SECOND INTERNATIONAL STANDARD FOR PROLACTIN.

D R BANGHAM, M V MUSSETT, M P STACK-DUNNE

    Bulletin of the World Health Organization
    |January 1, 1963
    PubMed
    Summary
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    The Second International Standard for Prolactin was established to replace the dwindling First International Standard. This new standard, with a defined potency, ensures continued accurate measurement of prolactin levels in biological assays.

    Area of Science:

    • Endocrinology
    • Biotechnology
    • Pharmacology

    Background:

    • The First International Standard for Prolactin was nearing depletion, necessitating a replacement.
    • The World Health Organization (WHO) Expert Committee on Biological Standardization initiated efforts to secure a new standard.
    • The National Institute for Medical Research, London, was tasked with preparing and evaluating the replacement material.

    Purpose of the Study:

    • To report on the characterization and handling of a proposed replacement material for the First International Standard for Prolactin.
    • To determine the potency of the proposed replacement material through international collaborative assay.
    • To establish the proposed material as the Second International Standard for Prolactin.

    Main Methods:

    • Characterization and preparation of the proposed replacement material for the International Standard for Prolactin.
    Keywords:
    BIOLOGICAL ASSAYBIRDSCHEMISTRY, PHARMACEUTICALELECTROPHORESISPOULTRYPROLACTIN

    Related Experiment Videos

  • International collaborative assay to compare the potency of the proposed material against the First International Standard.
  • Statistical analysis of assay results to define the potency and establish the Second International Standard.

    • Main Results:

    • The proposed replacement material was successfully characterized and prepared.
    • International collaborative assay confirmed the potency of the material.
    • The Second International Standard for Prolactin was established with a defined potency of 22 International Units (IU) per mg.

    Conclusions:

    • The Second International Standard for Prolactin has been established, ensuring the availability of a reliable reference material.
    • The defined potency of 22 IU/mg allows for accurate and consistent quantification of prolactin.
    • The International Unit of Prolactin is now defined based on the activity of the Second International Standard.