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[Intravenous immunoglobulins and anti-idiotypic suppression of auto-immunity]
1Service d'Immunologie, Hôpital Broussais, Paris.
This review summarizes the clinical use of intravenous immunoglobulins (IVIg) in autoimmune diseases and focuses on the mechanisms by which IVIg suppress autoimmune responses. Evidence is presented of a role of IVIg in modulating the regulatory function of the idiotypic network on the expression of the natural and pathological autoimmune repertoires.
This review summarizes the clinical use of intravenous immunoglobulins (IVIg) in autoimmune diseases and focuses on the mechanisms by which IVIg suppress autoimmune responses. Evidence is presented of a role of IVIg in modulating the regulatory function of the idiotypic network on the expression of the natural and pathological autoimmune repertoires.