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[Prophylaxis of malaria]
M Gentilini1, E Caumes, M Danis
1Département de médecine tropicale, Hôpital de la Salpêtrière, Paris.
La Revue De Medecine Interne
|May 1, 1992
Summary
Prevent malaria by avoiding mosquito bites and using antimalarial drugs for chemoprophylaxis. Drug choice depends on malaria resistance zones, with specific recommendations for travelers and treatment of resistant malaria.
Area of Science:
- Tropical Medicine
- Infectious Diseases
- Public Health
Background:
- Malaria prevention relies on vector control and chemoprophylaxis.
- Mosquito bite avoidance includes individual and collective measures.
- Chemoprophylaxis strategies vary based on geographic location and resistance patterns.
Purpose of the Study:
- To outline malaria prevention strategies.
- To define malaria endemic zones based on chemoresistance.
- To provide guidance on antimalarial drug selection for travelers.
Main Methods:
- Review of malaria prevention and treatment guidelines.
- Classification of endemic zones by drug resistance levels.
- Recommendations for chemoprophylaxis and treatment.
Main Results:
- Three endemic zones identified by chemoresistance.
- Key antimalarial drugs include chloroquine, proguanil, and mefloquine.
- Mefloquine is contraindicated for pregnant women and children.
Conclusions:
- Travelers should use antimalarials based on destination resistance and stay duration.
- Alternative treatments are advised when mefloquine is contraindicated.
- Quinine, halofantrine, and mefloquine are used for treating resistant malaria.