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[Acute nosocomial bacterial meningitis. Apropos 27 cases]
S M Dimitriu1, V Luca, T Turcu
1Clinica de boli Infecţioase, Universitatea de Medicină şi Farmacie Iaşi.
Abstract:
Our series includes 27 patients with nosocomial meningitis (22 post neurosurgery and 5 post spinal puncture) of whom 15 with stated etiology (gram-negative bacilli and staphylococcus aureus in equal shares). Under the treatment with chloramphenicol + rifampicin + gentamicin a cure was obtained in 22 cases, improvement in 3 cases and 2 patients died.
Insights
This study evaluated chloramphenicol, rifampicin, and gentamicin for treating nosocomial meningitis. The combination therapy showed high efficacy, curing 22 out of 27 patients.
Area of Science:
- Infectious Diseases
- Neuroscience
- Pharmacology
Context:
- Nosocomial meningitis presents a significant challenge, particularly in post-neurosurgical and post-spinal puncture patients.
- Gram-negative bacilli and Staphylococcus aureus are common etiologies.
- Limited treatment options exist for these severe infections.
Purpose:
- To assess the efficacy and outcomes of a combination therapy for nosocomial meningitis.
- To evaluate the effectiveness of chloramphenicol, rifampicin, and gentamicin in treating hospital-acquired meningitis.
Summary:
- A series of 27 patients with nosocomial meningitis (22 post-neurosurgery, 5 post-spinal puncture) were treated.
- Fifteen cases had identified pathogens, primarily Gram-negative bacilli and Staphylococcus aureus.
- Treatment with chloramphenicol, rifampicin, and gentamicin resulted in 22 cures and 3 improvements, with 2 deaths.
Impact:
- This combination therapy demonstrates a high success rate in treating nosocomial meningitis.
- The findings support the use of chloramphenicol, rifampicin, and gentamicin for managing hospital-acquired meningitis.
- Further research may explore optimizing this regimen for improved patient outcomes.