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[Acute nosocomial bacterial meningitis. Apropos 27 cases]
S M Dimitriu1, V Luca, T Turcu
1Clinica de boli Infecţioase, Universitatea de Medicină şi Farmacie Iaşi.
Summary
This study evaluated chloramphenicol, rifampicin, and gentamicin for treating nosocomial meningitis. The combination therapy showed high efficacy, curing 22 out of 27 patients.
Area of Science:
- Infectious Diseases
- Neuroscience
- Pharmacology
Context:
- Nosocomial meningitis presents a significant challenge, particularly in post-neurosurgical and post-spinal puncture patients.
- Gram-negative bacilli and Staphylococcus aureus are common etiologies.
- Limited treatment options exist for these severe infections.
Purpose:
- To assess the efficacy and outcomes of a combination therapy for nosocomial meningitis.
- To evaluate the effectiveness of chloramphenicol, rifampicin, and gentamicin in treating hospital-acquired meningitis.
Summary:
- A series of 27 patients with nosocomial meningitis (22 post-neurosurgery, 5 post-spinal puncture) were treated.
- Fifteen cases had identified pathogens, primarily Gram-negative bacilli and Staphylococcus aureus.
- Treatment with chloramphenicol, rifampicin, and gentamicin resulted in 22 cures and 3 improvements, with 2 deaths.
Impact:
- This combination therapy demonstrates a high success rate in treating nosocomial meningitis.
- The findings support the use of chloramphenicol, rifampicin, and gentamicin for managing hospital-acquired meningitis.
- Further research may explore optimizing this regimen for improved patient outcomes.