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Related Experiment Videos

[In vitro and in vivo acari tests].

M E Núñez-Núñez1, C Torres Lozano, A Pedroza Meléndez

  • 1Departamento de Alergia, Instituto Nacional de Pediatría, México, DF.

Revista Alergia : Organo Oficial De La Sociedad Mexicana De Alergia E Inmunlogia
|July 1, 1992
PubMed
Summary
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Clinical history and prick skin tests accurately diagnose house dust mite allergies in children. While total IgE showed poor correlation, specific allergen IgE (RAST) demonstrated a significant link.

Area of Science:

  • Allergen immunotherapy
  • Pediatric allergy diagnostics
  • Immunological assays

Context:

  • Perennial allergic diseases like asthma, rhinitis, and atopic dermatitis affect many children.
  • Accurate diagnosis of mite sensitivity is crucial for effective management.
  • Established diagnostic methods include skin prick tests and serum IgE measurements.

Purpose:

  • To evaluate the diagnostic utility of in vivo (prick skin test) and in vitro (total serum IgE, specific allergen IgE - RAST) tests for house dust mite allergy in children.
  • To assess the correlation between different diagnostic methods and clinical presentation.
  • To determine the most reliable diagnostic approach for mite-sensitive pediatric patients in our region.

Summary:

  • A study of 40 children with perennial allergic diseases found all had positive prick skin tests to mites (D. pteronissinus, D. farinae).

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  • Total serum IgE was elevated in 95% but showed poor, non-significant correlation with skin test reactivity.
  • Specific allergen IgE (RAST) was positive in 95% with a statistically significant correlation (r=0.31, p<0.05) to skin tests.

    • Impact:

    • Clinical history and prick skin tests are deemed sufficiently accurate for diagnosing mite-induced allergies in children in this region.
    • The findings support the continued use of these primary diagnostic tools, potentially reducing reliance on more complex or less correlated tests.
    • Highlights the importance of localized validation for allergy diagnostic methods.