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Prednisone is not a mouse carcinogen.

J E Dillberger¹, N S Cronin, G J Carr

¹Toxicology Department-Indianapolis Center, Marion Merrell Dow Inc., Indiana 46268-0470.

Toxicologic Pathology

|January 1, 1992

Summary

Long-term prednisone use, a synthetic corticosteroid, did not increase cancer risk in mice. In fact, prednisone significantly decreased the incidence of several tumor types, suggesting a potential cancer-protective effect.

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Area of Science:

Toxicology
Pharmacology
Oncology

Background:

Prednisone is a synthetic corticosteroid widely used for its anti-inflammatory and immunosuppressive properties.
Concerns exist regarding the long-term carcinogenic potential of corticosteroids.

Purpose of the Study:

To investigate the carcinogenic potential of prednisone in a long-term rodent study.
To determine if prednisone administration increases or decreases neoplasm incidence.

Main Methods:

Crl:CD-1(ICR) mice (50/sex/dose) were administered prednisone at doses of 0.25, 0.50, 1.0, and 5.0 mg/kg/day for 18 months.
Neoplasm incidence was statistically analyzed to assess treatment effects.

Main Results:

Prednisone did not significantly increase overall neoplasm incidence.
A significant decrease in hepatocellular tumors was observed in both male and female mice.
Prednisone also significantly reduced the incidence of male lacrimal/Harderian gland tumors, female pulmonary adenomas, female endothelial cell tumors, and female lymphosarcomas.

Conclusions:

Long-term prednisone administration does not appear to be carcinogenic in mice.
Prednisone demonstrated a significant cancer-reducing effect on specific tumor types in this study.
These findings suggest prednisone may have a protective role against certain cancers with prolonged use.

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