Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Neurulation

Neurulation

Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the anterior...

Cell Migration

Cell Migration

Cell migration, the process by which cells move from one location to another, is essential for the proper development and viability of organisms throughout their life. When cells are not able to migrate properly to their ordained locations, various disorders may occur. For example, disruption in cell migration causes chronic inflammatory diseases such as arthritis.

Cell Migration

Cell Migration

Cell migration is a process by which the cells move from one location to another, playing an essential role in embryological development, repair and regeneration, immune response, and metastasis. Cells migrate in response to chemical or mechanical signals generated by specific organs or tissues. The overall mechanism includes three steps - polarization, protrusion, and release. Polarization involves the formation of a distinct cell front and rear, which determines the direction of movement.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Histoplasmosis.

The American journal of digestive diseases·2010

Same author

Simultaneous radiographic and gastroscopic examination of the stomach.

Radiology·2010

Same author

An attempt to prevent histamine-induced ulcers in guinea pigs with benadryl (beta dimethylamino-ethylbenzhydryl ether hydrochloride).

The American journal of digestive diseases·2010

Same author

Correlative microscopy of cerebellar Bergmann glial cells.

Journal of submicroscopic cytology and pathology·2002

Same author

A common oocyst surface antigen of Cryptosporidium recognized by monoclonal antibodies.

Parasitology research·2002

Same author

The poor quality of information about laparoscopy on the World Wide Web as indexed by popular search engines.

Surgical endoscopy·2002

Same journal

Erratum for the Research Article "Detecting supramolecular organic nanoparticles during heat wave".

Science (New York, N.Y.)·2026

Same journal

Local signals, systemic decline.

Science (New York, N.Y.)·2026

Same journal

The mechanics of liver regeneration.

Science (New York, N.Y.)·2026

Same journal

Computing in a memory with physics.

Science (New York, N.Y.)·2026

Same journal

Retraction.

Science (New York, N.Y.)·2026

Same journal

Making time.

Science (New York, N.Y.)·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jun 20, 2026

Migratory Behavior of Cells Generated in Ganglionic Eminence Cultures

Migratory Behavior of Cells Generated in Ganglionic Eminence Cultures

Published on: April 21, 2011

Diverse migratory pathways in the developing cerebral cortex.

N A O'Rourke¹, M E Dailey, S J Smith

¹Department of Biological Sciences, Stanford University, CA 94305.

Science (New York, N.Y.)

|October 9, 1992

Summary

This summary is machine-generated.

During mammalian cerebral cortex development, young neurons migrate outward. Some neurons migrate radially along glial fibers, while others migrate orthogonally, potentially aiding neuronal dispersion.

More Related Videos

Ex Utero Electroporation and Organotypic Slice Cultures of Embryonic Mouse Brains for Live-Imaging of Migrating GABAergic Interneurons

Ex Utero Electroporation and Organotypic Slice Cultures of Embryonic Mouse Brains for Live-Imaging of Migrating GABAergic Interneurons

Published on: April 20, 2018

Time-Lapse Imaging of Migrating Neurons and Glial Progenitors in Embryonic Mouse Brain Slices

Time-Lapse Imaging of Migrating Neurons and Glial Progenitors in Embryonic Mouse Brain Slices

Published on: March 8, 2024

Related Experiment Videos

Last Updated: Jun 20, 2026

Migratory Behavior of Cells Generated in Ganglionic Eminence Cultures

Migratory Behavior of Cells Generated in Ganglionic Eminence Cultures

Published on: April 21, 2011

Ex Utero Electroporation and Organotypic Slice Cultures of Embryonic Mouse Brains for Live-Imaging of Migrating GABAergic Interneurons

Ex Utero Electroporation and Organotypic Slice Cultures of Embryonic Mouse Brains for Live-Imaging of Migrating GABAergic Interneurons

Published on: April 20, 2018

Time-Lapse Imaging of Migrating Neurons and Glial Progenitors in Embryonic Mouse Brain Slices

Time-Lapse Imaging of Migrating Neurons and Glial Progenitors in Embryonic Mouse Brain Slices

Published on: March 8, 2024

Area of Science:

Neuroscience
Developmental Biology
Cell Biology

Background:

During mammalian cerebral cortex development, newly formed neurons migrate from the ventricular zone to the cortical plate to establish the adult cortex.
Neuronal migration is a fundamental process for forming the complex neural circuitry of the brain.

Purpose of the Study:

To directly observe the dynamic behaviors of migrating neurons in living slices of the developing mammalian cerebral cortex.
To investigate the migratory pathways and behaviors of cortical neurons during early development.

Main Methods:

Utilized time-lapse confocal microscopy to visualize cellular dynamics in real-time.
Employed live tissue slices of the developing mammalian cerebral cortex for observation.

Main Results:

The majority of migrating neurons followed a radial pathway, aligning with migration along radial glial fibers.
A subset of neurons exhibited orthogonal migration within the intermediate zone, deviating from the radial path.
Observed orthogonal migration suggests a mechanism for tangential dispersion of clonally related neurons.

Conclusions:

Cortical neurons migrate along radial glial fibers, but a distinct population also migrates orthogonally.
Orthogonal migration may play a significant role in the tangential dispersion and spatial organization of cortical neurons.
Understanding these migration patterns is crucial for comprehending cortical development and potential developmental disorders.