Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Vascular toxicity associated with antineoplastic agents.

D C Doll1, J W Yarbro

  • 1Department of Medicine, University of Missouri, Columbia.

Seminars in Oncology
|October 1, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Unusual presentations of malignancy. Case 2. Breast plasmacytoma in a patient with human immunodeficiency virus.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology·2001
Same author

Severe bleeding complications in HIV-positive haemophiliac patients treated with protease inhibitors.

European journal of medical research·2001
Same author

Introductory remarks to the Conference on Prognostic Factors and Staging in Cancer Management: Contributions of Artificial Neural Networks and Other Statistical Methods.

Cancer·2001
Same author

A case of biliary carcinoid presenting with pancreatitis and obstructive jaundice.

The American journal of gastroenterology·2000
Same author

Prognostic factors in prostate cancer. College of American Pathologists Consensus Statement 1999.

Archives of pathology & laboratory medicine·2000
Same author

American Joint Committee on Cancer prognostic factors consensus conference.

Cancer·1999

Chemotherapy drugs like cisplatin can cause vascular issues such as Raynaud's phenomenon. Further research is needed to understand and prevent chemotherapy-induced vascular toxicity.

Area of Science:

  • Oncology
  • Pharmacology
  • Vascular Medicine

Background:

  • Vascular disorders are observed following antineoplastic agent administration.
  • The exact cause of these vascular issues (chemotherapy, malignancy, or other factors) remains unclear.
  • Specific chemotherapy agents are linked to distinct vascular toxicities.

Purpose of the Study:

  • To review and summarize the known vascular disorders associated with chemotherapy.
  • To highlight specific drug-toxicity relationships.
  • To discuss potential preventive strategies for severe complications like hepatic veno-occlusive disease (HVOD).

Main Methods:

  • Literature review of reported vascular complications from antineoplastic agents.
  • Identification of specific chemotherapy drugs and their associated vascular toxicities.

Related Experiment Videos

  • Discussion of emerging preventive measures for bone marrow transplantation complications.

    • Main Results:

    • Cisplatin, bleomycin, and vinblastine are associated with Raynaud's phenomenon.
    • 5-fluorouracil and high-dose cytarabine can cause painful acral erythema.
    • Mitomycin is a common cause of thrombotic microangiopathic syndrome.
    • Hepatic Veno-Oclusive Disease (HVOD) is a significant toxicity of bone marrow transplantation protocols.
    • Pentoxifylline and low-dose heparin show promise in preventing HVOD.
    • Chemotherapy regimens for breast cancer may be linked to thrombotic events.

    Conclusions:

    • A causal relationship exists between certain chemotherapies and specific vascular disorders.
    • Preventing chemotherapy-induced vascular toxicity, particularly HVOD, requires further investigation.
    • Prospective studies are necessary to confirm the link between chemotherapy and thrombotic events in breast cancer patients.
    • Elucidating the pathogenesis of chemotherapy-related vascular toxicity is crucial for patient management.