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Recurrence of neisserial meningococcemia due to deficiency of terminal complement component
1Infectious Disease Service, Brooke Army Medical Center, Fort Sam Houston, Tex. 78234-6200.
Abstract:
Recurrent infections with Neisseria meningitidis are attributed to deficiencies of terminal complement components. The serotype most commonly responsible for recurrent N meningitidis infections is serotype Y. We have reported a case of recurrent meningitis due to N meningitidis in a patient who was found to be deficient in the sixth component of complement. Complement deficiencies should be considered in any patient with recurrent infections caused by N meningitidis.
Insights
Recurrent Neisseria meningitidis infections, particularly serotype Y, can signal terminal complement component deficiencies. Consider complement deficiencies in patients with recurrent meningococcal infections.
Area of Science:
- Immunology
- Infectious Diseases
Background:
- Recurrent Neisseria meningitidis infections are often linked to deficiencies in the terminal complement system.
- Serotype Y is the most frequent cause of recurrent meningococcal infections.
Observation:
- A case of recurrent meningitis caused by Neisseria meningitidis was observed.
- The patient was diagnosed with a deficiency in the sixth complement component.
Findings:
- Deficiency in the sixth complement component can lead to recurrent Neisseria meningitidis infections.
- Terminal complement component deficiencies predispose individuals to meningococcal disease.
Implications:
- Complement deficiencies should be evaluated in patients presenting with recurrent Neisseria meningitidis infections.
- Identifying complement deficiencies is crucial for managing and preventing recurrent meningococcal disease.