Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Experimental immunogenic proliferative retinopathy in monkeys.

A L Shabo, D S Maxwell

    American Journal of Ophthalmology
    |April 1, 1977
    PubMed
    Summary

    Bovine serum albumin (BSA) injections in monkeys triggered immune responses in optic disk blood vessels. This immunogenic inflammation, particularly in sensitized subjects, led to optic nerve and retinal lesions, highlighting immune-mediated ocular damage.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    THE FINE STRUCTURE OF ASTROCYTES IN THE CEREBRAL CORTEX AND THEIR RESPONSE TO FOCAL INJURY PRODUCED BY HEAVY IONIZING PARTICLES.

    The Journal of cell biology·2009
    Same author

    Preparation of the human skull for skull base anatomic study.

    Skull base surgery·1993
    Same author

    Immunocytochemistry of alcohol dehydrogenase in the rat central nervous system.

    Alcoholism, clinical and experimental research·1989
    Same author

    Alcoholism.

    Annals of internal medicine·1984
    Same author

    Dendritic vacuolization in the central nervous system of rats after long-term voluntary consumption of ethanol.

    Journal of neuropathology and experimental neurology·1983
    Same author

    Blood-spinal cord barrier response to transection.

    Experimental neurology·1983

    Area of Science:

    • Ophthalmology
    • Immunology
    • Pathology

    Background:

    • The optic disk is a critical structure in the posterior segment of the eye.
    • Immune-mediated inflammation can affect ocular vasculature.
    • Understanding immune responses in the eye is crucial for managing ocular diseases.

    Purpose of the Study:

    • To investigate the immunogenic response in the optic disk vasculature following bovine serum albumin (BSA) injection in non-human primates.
    • To characterize the inflammatory and pathological changes associated with intravitreal BSA administration.
    • To explore the role of immune mechanisms in optic disk and retinal vascular lesions.

    Main Methods:

    • Intravitreal injections of bovine serum albumin (BSA) were administered to sensitized and non-sensitized monkeys.
    • Fluorescein angiography was used to detect vascular leakage.
    • Light and electron microscopy were employed to examine inflammatory cell infiltration and tissue damage.

    Main Results:

    • Intravitreal BSA induced immunogenic responses primarily in the optic disk vasculature of sensitized monkeys.
    • Repeated BSA injections in non-sensitized monkeys also elicited an inflammatory response.
    • Focal leaks, inflammatory cell infiltration, retinal hemorrhages, and exudative lesions were observed.
    • Proliferative lesions formed during the healing phase in cases of significant optic nerve involvement.

    Conclusions:

    • Immunologic mechanisms can preferentially target the optic disk vasculature, leading to significant ocular inflammation.
    • BSA-induced immunogenic inflammation can result in optic nerve damage and retinal vascular pathology.
    • The study demonstrates a model for immune-mediated optic disk and retinal vascular disease.

    Related Experiment Videos