Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Temporary lung support using an intravascular gas exchanger.

L K von Segesser1, B M Weiss, M Pasic

  • 1Clinic for Cardiovascular Surgery, University Hospital, Zürich, Switzerland.

The Thoracic and Cardiovascular Surgeon
|June 1, 1992
PubMed
Summary

This study evaluated an intravascular gas exchanger (IVOX) as an alternative to mechanical ventilation for severe respiratory failure. IVOX significantly improved blood gas exchange during hypoventilation in a bovine model.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Second primary malignancies in multiple myeloma: an overview and IMWG consensus.

Annals of oncology : official journal of the European Society for Medical Oncology·2017
Same author

Second primary malignancies in multiple myeloma: an overview and IMWG consensus.

Annals of oncology : official journal of the European Society for Medical Oncology·2016
Same author

Classifying ultra-high risk smoldering myeloma.

Leukemia·2014
Same author

Association between mobilization regimen and PFS after auto-SCT for multiple myeloma.

Bone marrow transplantation·2014
Same author

Bone marrow angiogenesis in myeloma and its precursor disease: a prospective clinical trial.

Leukemia·2013
Same author

Cellular immunotherapy for plasma cell myeloma.

Bone marrow transplantation·2013

Area of Science:

  • Critical Care Medicine
  • Respiratory Physiology
  • Biomedical Engineering

Background:

  • Severe respiratory failure often necessitates advanced mechanical ventilation techniques.
  • Extracorporeal circulation methods like ECMO are effective but demanding.
  • Intravascular gas exchange offers a potential alternative for respiratory support.

Purpose of the Study:

  • To evaluate the efficacy of an intravascular gas exchanger (IVOX) in a bovine model of severe respiratory failure.
  • To assess the impact of IVOX on blood gas parameters during induced hypoventilation.
  • To compare IVOX performance against conventional ventilation strategies.

Main Methods:

  • A reversible bovine model with endotracheal intubation and controlled ventilation was used (n=5).

Related Experiment Videos

  • An intravascular gas exchanger (siliconized microporous polypropylene hollow fibers) was placed in the caval veins.
  • Various ventilation scenarios, including normoventilation and hypoventilation with and without IVOX (100% O2 inlet), were studied.
  • Hemodynamic and blood gas parameters were analyzed after 15-minute stabilization periods.

    • Main Results:

    • IVOX significantly improved blood gas exchange during hypoventilation at FiO2 0.21.
    • Key improvements included increased pH (7.10 to 7.19) and PaO2 (6.5 to 7.3 kPa).
    • PaCO2 decreased (9.9 to 8.7 kPa), and mixed venous O2-saturation increased (33.9% to 48.1%).

    Conclusions:

    • Intravascular gas exchange (IVOX) demonstrates significant potential for improving gas exchange during hypoventilation.
    • IVOX offers a promising alternative or adjunct to conventional mechanical ventilation in critical respiratory failure.
    • Further research is warranted to explore the clinical applicability of IVOX in human patients.