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Preservation of renal function in chronic renal failure
J A Whitworth1, B U Ihle, G J Becker
1Department of Nephrology, Royal Melbourne Hospital, Victoria, Australia.
The Tohoku Journal of Experimental Medicine
|January 1, 1992
Summary
Chronic renal failure (CRF) progression factors differ between rats and humans. Management of underlying disease, diet, and hypertension is crucial for preserving kidney function and slowing chronic renal failure progression.
Area of Science:
- Nephrology
- Internal Medicine
Background:
- Mechanisms of chronic renal failure (CRF) progression in rats may not translate to humans.
- Multiple factors influence CRF progression, including underlying disease, diet, hypertension, and drug therapy.
Purpose of the Study:
- To review factors influencing chronic renal failure (CRF) progression in humans.
- To assess the impact of various interventions and conditions on renal function.
Main Methods:
- Literature review of factors affecting CRF progression.
- Discussion of clinical and experimental evidence.
- Reference to a prospective randomized study on protein restriction.
Main Results:
- Underlying disease type dictates progression; some conditions improve with management (e.g., malignant hypertension, analgesic nephropathy).
- Protein restriction showed benefit in preserving renal function in a prospective study.
- Hypertension, intercurrent events (sepsis, obstruction), and certain drugs can accelerate CRF progression.
Conclusions:
- Understanding the specific underlying renal disease is essential for predicting CRF progression.
- Dietary protein restriction and hypertension management are key therapeutic considerations.
- Further controlled studies are needed to evaluate drugs like converting enzyme inhibitors for renal protection.