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What is Genetic Engineering?00:49

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Protein-protein Interfaces02:04

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Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a polypeptide...
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Related Experiment Video

Updated: May 22, 2026

Engineering Cell-permeable Protein
21:08

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Published on: December 28, 2009

Protein engineering.

A Fersht1, G Winter

  • 1Cambridge University Chemical Laboratory, UK.

Trends in Biochemical Sciences
|August 1, 1992
PubMed
Summary
This summary is machine-generated.

Protein engineering has advanced therapeutic agents and protein analysis over ten years. Future goals include designing novel catalytic sites on proteins for new applications.

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Area of Science:

  • Biochemistry
  • Molecular Biology
  • Biotechnology

Background:

  • Protein engineering has a decade-long history of innovation.
  • Significant progress has been made in synthesizing novel therapeutic agents.
  • Analysis of protein structure, activity, specificity, stability, and folding pathways is crucial.

Purpose of the Study:

  • To review the advancements in protein engineering over the past ten years.
  • To highlight the synthesis of novel therapeutic agents.
  • To discuss the analysis of protein characteristics and the future potential for designing catalytic sites.

Main Methods:

  • Literature review of protein engineering studies from the past decade.
  • Analysis of published data on therapeutic agent synthesis.
  • Examination of research on protein structure-function relationships.

Main Results:

  • Successful synthesis of various novel therapeutic agents through protein engineering.
  • Comprehensive understanding gained on protein structure, activity, specificity, stability, and folding.
  • Demonstrated feasibility of modifying protein properties for specific functions.

Conclusions:

  • Protein engineering has matured significantly, yielding valuable therapeutic agents.
  • Further research holds promise for designing novel catalytic sites on proteins.
  • The field is poised for continued innovation in protein-based applications.