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Related Experiment Videos

Cell membrane-associated mucins and their adhesion-modulating property.

J Hilkens1, M J Ligtenberg, H L Vos

  • 1Division of Tumor Biology, Netherlands Cancer Institute, Antoni van Leeuwenhoekhuis, Amsterdam.

Trends in Biochemical Sciences
|September 1, 1992
PubMed
Summary

Highly sialylated glycoproteins reduce cell adhesion. In tumors, this loss of adhesion may promote invasion and metastasis by altering cell surface properties.

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Area of Science:

  • Biochemistry
  • Cell Biology
  • Oncology

Background:

  • Highly sialylated glycoproteins possess large mucin-like domains that extend from the plasma membrane.
  • These molecules are known to significantly decrease cellular adhesion.
  • In normal epithelial cells, their restricted expression to the luminal side prevents lumen closure.

Purpose of the Study:

  • To investigate the role of highly sialylated glycoproteins in cellular adhesion and tumor metastasis.
  • To understand how altered expression patterns in malignant tumors affect cell surface properties.

Main Methods:

  • Analysis of highly sialylated glycoprotein expression in normal and malignant epithelial cells.
  • Assessment of cellular adhesion and immune recognition properties in relation to glycoprotein coverage.

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Main Results:

  • In malignant tumors, loss of cellular polarization leads to widespread expression of these glycoproteins.
  • This results in significantly reduced cellular adhesion and immune recognition across the entire cell surface.

Conclusions:

  • Altered expression of highly sialylated glycoproteins in cancer contributes to reduced cell adhesion.
  • These changes are implicated in promoting tumor invasion and metastasis.