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DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications
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Electrostatic spraying of DNA molecules for investigation by scanning tunneling microscopy

T Thundat1, R J Warmack, D P Allison

  • 1Oak Ridge National Laboratory, TN 37831.

Ultramicroscopy
|July 1, 1992
PubMed

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Higher molecular weight biomolecules are nonvolatile compounds that may decompose before ionizing or vaporizing during mass analysis with conventional electron impact ionization methods. Accordingly, electrospray ionization (ESI) is the favored method for vaporizing and ionizing biomolecules as it circumvents rapid fragmentation and enables the recording of mass signals for the entire biomolecule.
ESI utilizes electrical energy to transfer ions from the liquid phase of the sample into the...