[3H]-ouabain binding to denervated and innervated skeletal muscle

In cat skeletal muscles, the major part of specific [3H]-ouabain binding was found in the sympathetic nerve endings of red, slow muscle fibres. Skeletal muscle denervation increased specific [3H]-ouabain binding to muscle membrane preparation. This increase may be involved in the development of spontaneous fibrillation in the denervated muscle.