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[A simple method using a maze task for estimating working memory in mice].

Y Masuda1, S Murai, H Saito

  • 1Department of Pharmacology, School of Dentistry, Iwate Medical University, Morioka, Japan.

Yakubutsu, Seishin, Kodo = Japanese Journal of Psychopharmacology
|February 1, 1992
PubMed
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This study introduces a T-maze task for assessing mouse working memory. The method effectively measures memory performance and the impact of drugs like scopolamine.

Area of Science:

  • Neuroscience
  • Animal Behavior
  • Cognitive Science

Background:

  • Working memory is crucial for cognitive function.
  • Developing reliable methods to assess working memory in rodents is essential for understanding memory mechanisms and testing potential therapeutics.
  • Traditional methods may have limitations in sensitivity or applicability.

Purpose of the Study:

  • To develop and validate a novel T-maze task for assessing spatial working memory in mice.
  • To evaluate the task's sensitivity to varying delay intervals.
  • To investigate the effects of a known working memory impairing agent, scopolamine, on task performance.

Main Methods:

  • Mice were trained on a T-maze task with a delayed alternation component.
  • The apparatus included specific features like a watering place, home cage access, bypasses, and one-way swinging doors.

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  • Varying delay intervals (5-150 s) were introduced between choices.
  • Scopolamine was administered at different doses (0.1-0.4 mg/kg) to assess its impact on performance.

    • Main Results:

    • Mice successfully acquired the alternation task at a 5-second delay by the 6th day.
    • Increasing the delay interval led to a gradual decrease in the correct response rate.
    • Scopolamine administration did not impair performance at a 5-second delay but significantly reduced the correct response rate at longer delays (30 s and 60 s).

    Conclusions:

    • The developed T-maze task is a sensitive and reliable method for estimating working memory capacity in mice.
    • The task effectively differentiates performance under varying delay conditions.
    • The results support the utility of this T-maze paradigm for preclinical research on memory and the evaluation of cognitive enhancers or disruptors.