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Updated: Sep 3, 2026

In Vivo Intracellular Recording of Type-Identified Rat Spinal Motoneurons During Trans-Spinal Direct Current Stimulation
Published on: May 11, 2020
[The effects of dantrolene sodium on the nervous system (author's transl)]
Abstract:
In order to investigate the effects of Dantrolene sodium on the nervous system, the experiments were carried out on cats. 1. Group Ia spindle afferent discharges were suppressed in 6 out of 14 cases following application of the drug. The effect lasted for 20 to 90 minutes. 2. No significant effects were observed on spinal mono- and polysynaptic reflexes, nor was seen on interneurons. However, 3 out of 9 Renshaw cells were facilitated and 3 were inhibited after Dantrolene sodium application. 3. Alternating discharges in the ventral root filaments, evoked by stimulation of N. cuneiformis, were suppressed by the drug application.
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