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Immunosuppression by whole-body irradiation and its effect on oedema in experimental cerebral ischaemia

R D Strachan1, P J Kane, S Cook

  • 1Department of Surgery (Neurosurgery), University of Newcastle-Upon-Tyne, England.

The effect of global immunosuppression by sublethal whole body X-irradiation on the development of cerebral oedema was assessed 24 h after right middle cerebral artery occlusion in the rat. Irradiation produced a significant leukopenia and thrombocytopaenia, and significantly reduced cortical oedema when compared to non-irradiated control animals.

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