[Study on pilules of indomethacin--PEG 6000]

Indomethacin (IDM)-PEG 6000 pilules were prepared using PEG 6000 as the carrier. The solubility of IDM in IDM-PEG 6000 pilules was about twice as much as pure IDM. When the effective dose of IDM-PEG 6000 was only half that of IDM tablet, the irritation of IDM-PEG 6000 pilule on rat stomach was reduced significantly but it still manifested the action of inhibiting the secretion of basal gastric acid.