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Related Experiment Videos

Macroprolactinomas: serial MR imaging in long-term bromocriptine therapy.

P Lundin1, K Bergström, R Nyman

  • 1Department of Diagnostic Radiology, Uppsala University, Akademiska sjukhuset, Sweden.

AJNR. American Journal of Neuroradiology
|September 1, 1992
PubMed
Summary

Long-term bromocriptine therapy effectively shrinks macroprolactinomas, with MRI revealing changes in tumor structure and optic chiasm. Serial MR imaging is valuable for monitoring treatment response and tumor evolution.

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Area of Science:

  • Endocrinology
  • Neuroradiology
  • Oncology

Background:

  • Macroprolactinomas are pituitary tumors that secrete prolactin.
  • Bromocriptine is a dopamine agonist used to treat macroprolactinomas.
  • Long-term effects of bromocriptine on macroprolactinomas require further investigation.

Purpose of the Study:

  • To evaluate macroprolactinoma changes during long-term bromocriptine therapy using serial MR imaging.
  • To correlate MR imaging findings with serum prolactin (S-PRL) levels.
  • To assess the impact of bromocriptine on tumor size, structure, and adjacent structures like the optic chiasm.

Main Methods:

  • Serial MR imaging (6-11 examinations) over 22-74 months in 13 patients with macroprolactinomas.
  • Evaluation of tumor size, extension, relationship to adjacent structures, and signal intensity patterns.

Related Experiment Videos

  • Calculation of signal intensity ratios and T2 values in solid tumor tissue.

    • Main Results:

    • Bromocriptine significantly reduced tumor size, often continuing for years; three cases showed re-enlargement.
    • Chiasmal herniation and cisternal invagination were common but not correlated with visual symptoms.
    • Increased T2 values after 1 year indicated higher water content in residual tumor tissue; hemorrhage was linked to high initial S-PRL levels.

    Conclusions:

    • MR imaging is crucial for monitoring bromocriptine therapy in macroprolactinoma patients.
    • Serial MRI provides insights into tumor size dynamics, internal structural changes, and optic chiasm interactions.
    • Findings highlight the utility of MR imaging in understanding long-term treatment effects on macroprolactinomas.