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Serum creatinine level and renal function in children.

J E Springate1, S L Christensen, L G Feld

  • 1Division of Nephrology, Children's Hospital of Buffalo, NY.

American Journal of Diseases of Children (1960)
|October 1, 1992
PubMed
Summary
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The height/serum creatinine glomerular filtration rate (Cr-GFR) formula accurately screens for abnormal kidney function in children. This method is more effective than serum creatinine alone for detecting renal insufficiency and failure.

Area of Science:

  • Pediatric Nephrology
  • Diagnostic Accuracy
  • Renal Function Testing

Background:

  • Abnormal renal function in children requires accurate screening methods.
  • Serum creatinine levels and the height/serum creatinine glomerular filtration rate (Cr-GFR) formula are potential screening tools.

Purpose of the Study:

  • To compare the accuracy of serum creatinine and the Cr-GFR formula in identifying impaired renal function in pediatric patients.

Main Methods:

  • Evaluated 87 pediatric patients (ages 2-20) using plasma diethylenetriaminepenta-acetic acid (DTPA) clearance as the reference standard.
  • Calculated Cr-GFR using the formula: GFR = kL/serum creatinine.

Main Results:

  • The Cr-GFR formula demonstrated high sensitivity (95%) and specificity (93%) for detecting impaired renal function (DTPA clearance < 80 mL/min/1.73 m2).

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  • The Cr-GFR formula identified 91% of children with renal insufficiency (DTPA clearance 40-79 mL/min/1.73 m2), compared to 65% with elevated serum creatinine.
  • The Cr-GFR formula showed superior specificity (100%) compared to serum creatinine (75%) in identifying renal failure (DTPA clearance < 40 mL/min/1.73 m2).

    • Conclusions:

    • The Cr-GFR formula is a more accurate and reliable screening test for estimating glomerular filtration rate (GFR) in children than serum creatinine alone.
    • The Cr-GFR formula offers a simple and effective method for assessing the presence and severity of impaired renal function in pediatric populations.