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Helicobacter pylori-negative gastric ulcer
T J Borody1, S Brandl, P Andrews
1Centre for Digestive Diseases, Sydney, Australia.
The American Journal of Gastroenterology
|October 1, 1992
Summary
Around 11% of gastric ulcers (GUs) have no identifiable cause, termed "idiopathic GU." Helicobacter pylori (HP)-negative ulcers are frequently linked to nonsteroidal anti-inflammatory drug (NSAID) use.
Area of Science:
- Gastroenterology
- Internal Medicine
- Pathophysiology
Background:
- Gastric ulcers (GUs) are common, but causes for Helicobacter pylori (HP)-negative cases are understudied.
- Identifying the etiology of GUs is crucial for effective management strategies.
Purpose of the Study:
- To systematically investigate the potential causes of HP-negative gastric ulcers.
- To determine the prevalence of idiopathic GUs and associated risk factors.
Main Methods:
- Endoscopic diagnosis of gastric ulcers in 115 consecutive patients.
- Assessment for Helicobacter pylori infection.
- Evaluation of nonsteroidal anti-inflammatory drug (NSAID) use and malignancy as potential causes.
Main Results:
- Of 115 patients, 71 (62%) were HP-positive and 44 (38%) were HP-negative.
- Among HP-negative GUs, 66% were attributed to NSAID use, 5% to malignancy, and 30% (11% of total) were classified as idiopathic.
- HP-positive ulcers were more frequently located on the lesser curve (76%) compared to prepyloric ulcers (52%).
Conclusions:
- A significant proportion of gastric ulcers, particularly HP-negative ones, are associated with NSAID use.
- Approximately 11% of gastric ulcers remain idiopathic, lacking identifiable causes.
- Understanding the specific cause of gastric ulcers, whether HP-related, NSAID-induced, or idiopathic, is essential for guiding clinical treatment.