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Published on: March 8, 2018
Renal hemodynamics in recent-onset type II diabetes
Summary
Glomerular hyperfiltration, an indicator of kidney disease, is common in recent-onset type II diabetes. This study found elevated glomerular filtration rate (GFR) in 44% of patients, suggesting hyperfiltration is prevalent in this population.
Area of Science:
- Nephrology
- Endocrinology
- Diabetology
Background:
- Diabetic nephropathy is a significant complication of diabetes.
- Glomerular hyperfiltration is implicated in diabetic nephropathy pathogenesis.
- Evidence for hyperfiltration in type II diabetes is inconsistent.
Purpose of the Study:
- To investigate the prevalence of glomerular hyperfiltration in nonproteinuric, recently diagnosed type II diabetes patients.
- To compare renal hemodynamics in type II diabetics with healthy and obese controls.
Main Methods:
- Measured glomerular filtration rate (GFR) and effective renal plasma flow (ERPF) using inulin and p-aminohippuric acid clearance.
- Assessed renal hemodynamics in 16 nonproteinuric type II diabetics, 31 healthy volunteers, and 6 obese controls.
- Measured lean body mass using densitometry.
Main Results:
- Median GFR was significantly higher in type II diabetics (133 mL/min/1.73 m2) compared to obese controls (118 mL/min/1.73 m2).
- Elevated GFR (>95th percentile of controls) was observed in 44% of patients, and 50% when adjusted for lean body mass.
- GFR did not correlate with glycemic control (fasting glucose, HbA1C) or growth factors (IGF-1, IGF-2, SMBP).
Conclusions:
- Hyperfiltration is a common finding in patients with recent-onset type II diabetes.
- These findings highlight the importance of monitoring renal function in early type II diabetes.
- Further research is needed to understand the long-term implications of hyperfiltration in type II diabetes.
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