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Acute isoniazid poisoning.

A Gurnani1, R Chawla, P Kundra

  • 1Department of Anaesthesiology, University College of Medical Sciences, Delhi, India.

Anaesthesia
|September 1, 1992
PubMed
Summary
This summary is machine-generated.

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Two patients experienced acute isoniazid poisoning after intentional overdose, presenting with unconsciousness, breathing difficulties, and seizures. Complications included liver damage and peripheral nerve issues, highlighting severe toxicity risks.

Area of Science:

  • Toxicology
  • Pharmacology
  • Neurology

Background:

  • Isoniazid is a primary treatment for tuberculosis.
  • Intentional overdose can lead to severe toxic effects.

Observation:

  • Two patients ingested large doses of isoniazid (7.5g and 5.0g) for suicide attempts.
  • Both presented with altered consciousness, respiratory compromise, and seizures upon admission.

Findings:

  • Acute isoniazid poisoning manifested with significant central nervous system and respiratory depression.
  • Key complications observed were hepatic dysfunction and the development of peripheral neuropathy.

Implications:

  • This case series underscores the critical need for prompt recognition and management of severe isoniazid toxicity.

Related Experiment Videos

  • Highlights the potential for serious adverse events, including neurological and hepatic damage, following intentional isoniazid overdose.