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Related Experiment Videos

Lung traction causes an increase in plasma prostacyclin concentration and decrease in mean arterial blood pressure.

M Matsumoto1, K Ohki, I Nagai

  • 1Department of Anesthesiology, University of California, San Diego, La Jolla.

Anesthesia and Analgesia
|November 1, 1992
PubMed
Summary

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Lung traction during surgery can decrease blood pressure and cause flushing by increasing prostacyclin levels. These effects are temporary and reversible after the traction is released.

Area of Science:

  • Cardiovascular Physiology
  • Pulmonary Medicine
  • Prostaglandin Research

Background:

  • Lung traction is a maneuver used during thoracic surgery.
  • The physiological effects of lung traction on systemic circulation are not fully understood.

Purpose of the Study:

  • To investigate the impact of lung traction on arterial blood pressure.
  • To assess changes in plasma prostacyclin concentrations following lung traction.
  • To identify associated clinical signs and their duration.

Main Methods:

  • Studied five patients undergoing lung resection (partial pneumonectomy or lobectomy).
  • Monitored mean arterial blood pressure before and after manual lung traction.
  • Measured plasma concentrations of 6-keto prostaglandin F1 alpha, a prostacyclin metabolite.

Related Experiment Videos

  • Observed for clinical signs like facial flushing and palmar erythema.

    • Main Results:

    • Mean arterial blood pressure decreased significantly after lung traction (77 to 59 mm Hg).
    • Plasma prostacyclin metabolite levels increased dramatically (46 to 593 pg/mL).
    • Four patients experienced transient facial flushing and palmar erythema.
    • Blood pressure and symptoms resolved within 30 minutes post-traction.

    Conclusions:

    • Lung traction appears to stimulate prostacyclin release or production.
    • Increased prostacyclin mediates the observed decrease in blood pressure and cutaneous vasodilation.
    • These physiological responses are transient and reversible upon cessation of lung traction.