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Related Experiment Videos

Budesonide in grass pollen rhinitis.

P S Norman1, P S Creticos, R Tobey

  • 1Johns Hopkins Asthma and Allergy Center, Baltimore, MD 21224.

Annals of Allergy
|October 1, 1992
PubMed
Summary

Budesonide nasal spray significantly reduced allergic rhinitis symptoms like sneezing and stuffy nose compared to placebo. This study found budesonide effective for seasonal allergic rhinitis without significant adverse effects.

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Area of Science:

  • Allergy and Immunology
  • Pharmacology
  • Respiratory Medicine

Background:

  • Seasonal allergic rhinitis (SAR) affects millions globally.
  • Nasal glucocorticoids are a primary treatment for SAR.
  • Budesonide is a widely used nasal glucocorticoid.

Purpose of the Study:

  • To evaluate the efficacy of budesonide nasal spray versus placebo in adults with grass pollen-induced SAR.
  • To compare the incidence of adverse experiences between budesonide and placebo.
  • To assess the systemic glucocorticoid effect of budesonide nasal spray.

Main Methods:

  • A 4-week, randomized, double-blind, placebo-controlled trial involving 50 adult patients with SAR.
  • Budesonide nasal spray (100 mcg/nostril twice daily) was compared to placebo.

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  • Symptom diaries, investigator assessments, and biochemical markers (plasma cortisol, 17-hydroxycorticosteroid, TAME esterase) were used.

    • Main Results:

    • Budesonide significantly reduced sneezing, nasal congestion, and nasal secretion scores compared to placebo (P < .001).
    • No significant differences were observed in eye itch or rescue medication use.
    • Budesonide treatment led to a significant decrease in TAME esterase levels in nasal secretions.

    Conclusions:

    • Budesonide nasal spray is an effective treatment for seasonal allergic rhinitis symptoms.
    • The study demonstrated a favorable efficacy and safety profile for budesonide in SAR management.
    • Budesonide nasal spray effectively reduces nasal inflammation markers in allergic rhinitis patients.