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Monitoring Dynamic Growth of Retinal Vessels in Oxygen-Induced Retinopathy Mouse Model
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Published on: April 2, 2021

THE PRESENT STATUS OF RETROLENTAL FIBROPLASIA

J M JORDAN

    California Medicine
    |April 1, 1964
    PubMed

    Insights

    Retrolental fibroplasia (RLF) incidence in premature infants has decreased with reduced oxygen use. However, RLF still occurs in infants with respiratory distress, especially when oxygen levels exceed 40%.

    Area of Science:

    • Neonatal ophthalmology
    • Pediatric critical care

    Background:

    • Retrolental fibroplasia (RLF) is a significant cause of blindness in premature infants.
    • Reduced oxygen administration has decreased RLF rates, but cases persist.

    Purpose of the Study:

    • To summarize the current understanding of retrolental fibroplasia incidence and contributing factors in premature infants.
    • To highlight the continued occurrence of RLF despite reduced oxygen exposure.

    Main Methods:

    • Review of clinical observations and institutional data regarding RLF cases.
    • Analysis of oxygen administration practices and their correlation with RLF incidence.

    Main Results:

    • Significant reduction in RLF incidence following decreased oxygen concentration and duration.
    • Continued occurrence of RLF in premature infants with respiratory distress and cyanosis.
    • Lowest RLF incidence observed when supplemental oxygen never exceeds 40%.

    Conclusions:

    • While oxygen reduction has lowered RLF rates, it remains a concern for vulnerable premature infants.
    • The precise mechanism of oxygen-induced retinal vessel obliteration requires further investigation.
    • Adherence to strict oxygen limits (≤40%) appears crucial for preventing RLF.

    Keywords:
    INFANT, NEWBORNMATERNAL-FETAL EXCHANGEOXYGENPATHOLOGYPREGNANCYRETINAL DETACHMENTRETINAL VESSELSRETROLENTAL FIBROPLASIA

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