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BORIC ACID POISONING: REPORT OF 11 CASES

L C WONG, M D HEIMBACH, D R TRUSCOTT

    Canadian Medical Association Journal
    |April 25, 1964
    PubMed

    Insights

    Accidental boric acid formula contamination led to poisoning in 11 infants, causing severe symptoms and five deaths. Peritoneal dialysis was effective, highlighting the need to remove boric acid from medical settings.

    Area of Science:

    • Toxicology
    • Pediatrics
    • Neonatal Care

    Background:

    • Boric acid was inadvertently used in infant formula preparation in a newborn nursery.
    • This led to accidental poisoning in 11 infants.

    Purpose of the Study:

    • To report on a series of boric acid poisoning cases in infants.
    • To evaluate treatment methods and recommend preventative measures.

    Main Methods:

    • Case series reporting on 11 infants with boric acid poisoning.
    • Clinical observation of symptoms and treatment outcomes.
    • Evaluation of peritoneal dialysis as a treatment modality.

    Main Results:

    • Five out of 11 infants died.
    • Classical symptoms included diarrhea, vomiting, erythema, exfoliation, and central nervous system irritation.
    • Peritoneal dialysis was the most effective treatment in nine cases.

    Conclusions:

    • Boric acid poisoning in infants can be severe and fatal.
    • Prompt treatment, such as peritoneal dialysis, is crucial.
    • Boric acid should be removed from hospitals and pharmacopoeias due to its risks and limited therapeutic value.

    Keywords:
    ACIDOSISBORATESCOLOR PERCEPTION TESTSCONVULSIONSDEHYDRATIONDIARRHEA, INFANTILEERYTHEMAEXCHANGE TRANSFUSIONGASTRIC LAVAGEHYPERNATREMIAINFANTINFANT, NEWBORNPERITONEAL DIALYSISPHENOBARBITALTETRACYCLINETOXICOLOGIC REPORTVOMITING

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