Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Lethal Alleles02:41

Lethal Alleles

Agouti: A Lethal Allele
Lucien Cuénot discovered lethal alleles in 1905 while studying the inheritance of coat color in mice. The agouti gene is responsible for the color of the coat in mice. This gene codes for an agouti-signaling protein, which is responsible for melanin distribution in mammals. The wild-type allele gives rise to gray-brown coat color in mice, while the mutant allele gives rise to yellow coat color. In addition to coat color, the agouti gene is associated with the yellow...
Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A neuropharmacological evaluation of enprostil in animals.

Proceedings of the Western Pharmacology Society·1989
Same author

Inhibition of leukotriene and thromboxane biosynthesis by a 9-(4-chlorophenyl) analogue of arachidonic acid.

Journal of pharmaceutical sciences·1988
Same author

Resolution of (+/-)-2-tetradecyloxiranecarboxylic acid. Absolute configuration and chiral synthesis of the hypoglycemic R enantiomer and biological activity of enantiomers.

Journal of medicinal chemistry·1987
Same author

Synthesis and gastric antisecretory properties of allenic 16-phenoxy-omega-tetranor prostaglandin E analogs.

Prostaglandins·1987
Same author

Gastric antisecretory and antiulcer properties of enprostil, (+/-)-11 alpha, 15 alpha-dihydroxy-16-phenoxy-17,18,19,20-tetranor-9-oxoprosta- 4,5,13(t)-trienoic acid methyl ester.

The Journal of pharmacology and experimental therapeutics·1986
Same author

Alkylglycidic acids: potential new hypoglycemic agents.

Journal of medicinal chemistry·1986

Related Experiment Video

Updated: Jun 30, 2026

Chronic Salmonella Infected Mouse Model
09:01

Chronic Salmonella Infected Mouse Model

Published on: June 1, 2010

SELECTIVE RAT TOXICANT.

A P ROSZKOWSKI, G I POOS, R J MOHRBACHER

    Science (New York, N.Y.)
    |April 24, 1964
    PubMed
    Summary

    The maleimide adduct of an unusual fulvene shows high toxicity in rats. However, common pets and commercially useful animals exhibit no significant toxic effects even at much higher doses.

    Area of Science:

    • Toxicology
    • Organic Chemistry

    Background:

    • Fulvenes are a class of organic compounds.
    • Maleimide adducts can exhibit biological activity.

    Purpose of the Study:

    • To assess the toxicity of a specific maleimide adduct of an unusual fulvene.
    • To compare toxicity across different animal species.

    Main Methods:

    • Oral and parenteral administration of the maleimide adduct to rats.
    • Administration of high doses to common house pets, commercially useful mammals, and birds.

    Main Results:

    • The maleimide adduct proved highly toxic to rats.
    • No significant toxic or biological changes were observed in pets, mammals, and birds at doses 200 times higher than the lethal dose for rats.
    Keywords:
    CATTLECHEMISTRY, ANALYTICALDOGSEXPERIMENTAL LAB STUDYGUINEA PIGSHORSESMONKEYSPOULTRYRABBITSRATSRODENTICIDESSHEEPSPECIES SPECIFICITYTOXICOLOGIC REPORT

    More Related Videos

    Social Threat-Safety Test Uncovers Psychosocial Stress-Related Phenotypes
    05:03

    Social Threat-Safety Test Uncovers Psychosocial Stress-Related Phenotypes

    Published on: December 15, 2023

    A Multiple Integrated Social Stress Model for Psychiatric Disorders in Female C57BL/6J Mice
    06:15

    A Multiple Integrated Social Stress Model for Psychiatric Disorders in Female C57BL/6J Mice

    Published on: July 15, 2025

    Related Experiment Videos

    Last Updated: Jun 30, 2026

    Chronic Salmonella Infected Mouse Model
    09:01

    Chronic Salmonella Infected Mouse Model

    Published on: June 1, 2010

    Social Threat-Safety Test Uncovers Psychosocial Stress-Related Phenotypes
    05:03

    Social Threat-Safety Test Uncovers Psychosocial Stress-Related Phenotypes

    Published on: December 15, 2023

    A Multiple Integrated Social Stress Model for Psychiatric Disorders in Female C57BL/6J Mice
    06:15

    A Multiple Integrated Social Stress Model for Psychiatric Disorders in Female C57BL/6J Mice

    Published on: July 15, 2025

    Conclusions:

    • The maleimide adduct of the unusual fulvene exhibits species-specific toxicity.
    • Rats are highly susceptible, while common domestic and commercial animals show remarkable tolerance.