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Toxic shock-like syndrome caused by adenovirus infection
1Infectious Disease Unit, Hospitals for Sick Children, London.
Archives of Disease in Childhood
|September 1, 1992
Insights
Adenovirus infections can affect multiple organ systems in children. This report details a rare case of toxic shock-like syndrome caused by adenovirus, leading to multiorgan failure.
Area of Science:
- Virology
- Pediatric Infectious Diseases
- Critical Care Medicine
Background:
- Adenovirus infections are common in children, typically affecting the respiratory and gastrointestinal systems.
- While generally mild, adenoviruses can cause severe disease impacting various organ systems.
Observation:
- A pediatric case presented with symptoms mimicking toxic shock-like syndrome.
- The patient exhibited signs of widespread inflammation and dysfunction across multiple organ systems.
Findings:
- Adenovirus was identified as the causative agent of the severe illness.
- The infection led to a complex clinical picture of multiorgan involvement.
Implications:
- This case highlights the potential for adenoviruses to cause severe, systemic inflammatory syndromes beyond typical presentations.
- Clinicians should consider adenovirus in the differential diagnosis of pediatric toxic shock-like syndrome with multiorgan failure.
- Further research into adenovirus pathogenesis and severe disease manifestations is warranted.
Abstract:
Adenovirus infections commonly occur in childhood and produce a wide range of clinical disease. The most common sites of infection are the respiratory and gastrointestinal tracts but involvement of cardiovascular, neurological, cutaneous, ophthalmic, renal, and hepatic systems can also occur. A case of toxic shock-like syndrome with symptoms of multiorgan involvement resulting from adenovirus infection is reported.