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Evaluation of a Novel Laser-assisted Coronary Anastomotic Connector - the Trinity Clip - in a Porcine Off-pump Bypass Model
Published on: November 24, 2014
Surgical considerations in bypassing coronary arteries with 100% proximal occlusion
T R McLean1, L G Svensson, B Stein
1Cora and Webb Madding Department of Surgery, Baylor College of Medicine, Houston, Texas.
Insights
Cineangiography significantly overestimates the size of totally occluded coronary arteries. This impacts bypass grafting site selection and can lead to increased creatine kinase-MB levels post-procedure.
Area of Science:
- Cardiovascular medicine
- Interventional cardiology
- Cardiac imaging
Background:
- Limited objective data exists on cineangiography's accuracy in predicting coronary artery size for totally occluded vessels.
- Clinical outcomes following revascularization of totally occluded coronary arteries require further clarification.
Purpose of the Study:
- To evaluate the accuracy of cineangiography in determining the size of totally occluded coronary arteries.
- To compare the actual vessel size with cineangiographic measurements.
- To assess the clinical outcomes of revascularization in patients with totally versus subtotally occluded coronary arteries.
Main Methods:
- A review of 200 consecutive coronary revascularization cases.
- Categorization into Group I (totally occluded, n=57) and Group II (subtotally occluded, n=143).
- Blind review of cineangiograms to measure vessel size, compared with intraoperative measurements.
Main Results:
- Cineangiography significantly overestimated the size of totally occluded arteries (1.9 mm vs. 1.6 mm actual, p=0.00004).
- No significant size difference was found for subtotally occluded arteries (1.8 mm vs. 1.8 mm actual).
- Bypass graft sites were smaller in the totally occluded group (1.6 mm vs. 1.8 mm, p=0.00008), with higher late creatine kinase-MB rise.
Conclusions:
- Cineangiography is inaccurate for assessing the size of totally occluded coronary arteries.
- Overestimation of vessel size may influence surgical decisions and impact outcomes.
- Further research is needed to refine imaging techniques and improve revascularization strategies.
Abstract:
Objective data on the ability of cineangiography to predict the size of reconstituted totally occluded coronary arteries, as well as the clinical outcome of such revascularization, are sparse. Accordingly, we reviewed 200 consecutive cases of coronary revascularization to determine the answers to these questions. Group I patients (n = 57, with 86 totally occluded coronary arteries) had at least one coronary artery with a 100% proximal occlusion that reconstituted distally. Group II patients (n = 143, with 205 subtotally occluded coronary arteries) had 50% to 99% proximal stenosis of at least one coronary artery. Cineangiograms were blindly reviewed to measure the size of the coronary arteries, which were compared with the actual vessel size at operation. In group I, the totally occluded coronary arteries had a cineangiographic size of 1.9 +/- 0.7 mm and an actual size of 1.6 +/- 0.4 mm (p = 0.00004). In group II, the subtotally occluded coronary arteries had a cineangiographic size of 1.8 +/- 0.4 mm compared with an actual size of 1.8 +/- 0.3 mm (p = not significant). The site of bypass grafting was significantly smaller in group I (1.6 +/- 0.4 mm versus 1.8 +/- 0.3 mm; p = 0.00008). The two groups were similar with respect to preoperative and intraoperative parameters. Operative mortalities were similar (group I, 1.8%; group II, 3.5%; p = 0.68). Creatine kinase isoenzyme profiles and electrocardiographic changes were similar, except for a significant late rise of creatine kinase-MB in group I (56.1 +/- 14.7 versus 30.7 +/- 33.7 MIU/mL; p < 0.001). In conclusion, cineangiography significantly overestimates the size of totally occluded coronary arteries.(ABSTRACT TRUNCATED AT 250 WORDS)
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