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Synthesis and antimicrobial activity of 3-(substituted-phenyl)-sydnones
1Department of Medicinal Chemistry, Faculty of Pharmacy, University of Mansoura, Egypt.
Archiv Der Pharmazie
|July 1, 1992
Abstract:
3-(3 or 4-Acetylphenyl)-sydnones 7, 8 have been synthesized by formation of the glycines 3, 4, followed by nitrosation to 5, 6 and cyclization with acetic anhydride to sydnones. Sydnone derivatives carrying chalcone moieties 15, 16 were prepared by formation of the chalcone analogues 11, 12 through condensation of the glycines 3, 4 with the appropriate aldehydes, followed by the reactions applied for the preparation of 7, 8. The sydnone derivatives were screened for antimicrobial activities.