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HISTOPLASMIN SENSITIVITY OF YOUNG MEN IN ALASKA, HAWAII, THE PHILIPPINES AND PUERTO RICO.

P Q EDWARDS

    Bulletin of the World Health Organization
    |January 1, 1964
    PubMed
    Summary

    Skin sensitivity to histoplasmin varies among US Navy recruits. Large reactions in Puerto Rican and Filipino recruits suggest Histoplasma infection, while smaller reactions in others may indicate cross-reactions to unknown agents.

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    Area of Science:

    • Immunology
    • Infectious Diseases
    • Epidemiology

    Background:

    • Histoplasmin skin testing is used to assess exposure to Histoplasma, a fungal pathogen.
    • Variations in skin test reactivity can indicate differences in infection prevalence or exposure to cross-reactive agents.
    • Previous studies have shown regional differences in reactivity to fungal antigens.

    Purpose of the Study:

    • To investigate geographic variations in skin sensitivity to histoplasmin among United States Navy recruits.
    • To differentiate between specific Histoplasma infection and cross-reactions based on skin test results.

    Main Methods:

    • Skin sensitivity testing using histoplasmin was performed on Navy recruits from diverse geographic locations including Alaska, Hawaii, the Philippines, Puerto Rico, and mainland United States.
    Keywords:
    ALASKACOCCIDIOIDESHAWAIIHISTOPLASMINHISTOPLASMOSISPHILIPPINESPUERTO RICOSKIN TESTSSTATISTICSUNITED STATES

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  • Reactions were categorized based on size to infer specific infection versus cross-reactivity.

    • Main Results:

    • Recruits from Puerto Rico and the Philippines exhibited frequent, large reactions to histoplasmin.
    • Recruits from Hawaii and the Philippines showed smaller reactions, suggesting cross-reactivity.
    • Recruits from mainland United States showed varying degrees of reaction.

    Conclusions:

    • Large histoplasmin reactions in Puerto Rican and Filipino recruits are indicative of specific Histoplasma infection.
    • Smaller reactions observed in recruits from Hawaii and the Philippines likely represent cross-reactions due to sensitization by an unidentified environmental agent or agents.
    • Geographic origin is a significant factor in interpreting histoplasmin skin test results.