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Synthesis of 6-substituted tetrazolo[1,5-c]pyrimidin-5(6H)ones: new modification of 3'-azido-3'-deoxythymidine
K Ciszewski1, L Celewicz, K Golankiewicz
1Faculty of Chemistry, Adam Mickiewicz University, Poznan, Poland.
Biochemical and Biophysical Research Communications
|September 30, 1992
Abstract:
An efficient method for the preparation of 6-methyltetrazolo-[1,5-c]pyrimidin-5(6H)ones using as the precursors 4-chloro-1,2-dihydro-1-methyl-2-oxopyrimidines is described. The method is also extended to the synthesis of novel tetrazole analogue of 3'-azido-3'-deoxythymidine (AZT).