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A vasopressor factor partially purified from human parathyroid glands
H Schlüter1, C Quante, B Buchholz
1Med. Poliklinik, University of Münster, Germany.
Biochemical and Biophysical Research Communications
|October 15, 1992
Summary
Researchers identified a novel vasopressor substance in human parathyroid glands. This hydrophilic peptide may contribute to hypertension, distinct from parathyroid hormone.
Area of Science:
- Endocrinology
- Nephrology
- Cardiovascular Research
Background:
- A parathyroid hypertensive factor has been proposed in genetically hypertensive rats.
- The role of parathyroid glands in human hypertension remains unclear.
Purpose of the Study:
- To investigate the presence and characteristics of a vasopressor substance in human parathyroid glands.
Main Methods:
- Homogenates of hyperplastic parathyroid glands from 20 patients were processed.
- Gel chromatography was used for fractionation.
- Fractions were tested for vasopressor activity using isolated perfused rat kidneys.
Main Results:
- A vasopressor fraction with molecular weight of 0.6-2.5 kDa was detected.
- The substance was heat-sensitive and sensitive to peptidases (trypsin, carboxypeptidase y).
- It was hydrophilic, not binding to hydrophobic reversed-phase gel.
Conclusions:
- Human parathyroid glands contain a hydrophilic, peptide-like vasopressor substance.
- This substance is distinct from parathyroid hormone.
- It may play a role in the pathogenesis of hypertension.