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MYELOMATOSIS WITH XANTHOMATOSIS MULTIFORME
Canadian Medical Association Journal
|August 22, 1964
Summary
This study links rare conditions xanthomatosis and myelomatosis in a patient with hypercholesterolemia. Abnormal plasma cells in bone marrow likely produced myeloma lipoproteins, elevating cholesterol.
Area of Science:
- Biochemistry
- Hematology
- Lipid Metabolism
Background:
- Simultaneous occurrence of xanthomatosis (associated with hypercholesterolemia) and myelomatosis is rare.
- Patient presented with extremely high cholesterol levels, predominantly in the beta-lipoprotein fraction.
Purpose of the Study:
- To investigate the direct association between xanthomatosis and myelomatosis.
- To identify the source and nature of the abnormal lipoproteins in the patient's blood.
Main Methods:
- Electrophoresis and ultracentrifugation were used to analyze lipoprotein fractions.
- Chemical composition and C(14)-labeled precursor incorporation studies were performed.
- Longitudinal studies were conducted over a six-year period.
Main Results:
- A direct association between myelomatosis and hypercholesterolemia was established.
- Abnormal myeloma lipoproteins were identified as the likely source of elevated cholesterol.
- Low-density lipoproteins (S(f) 0-12) were primarily implicated.
Conclusions:
- Myelomatosis can lead to severe hypercholesterolemia through the production of abnormal lipoproteins by plasma cells.
- This case highlights a unique interaction between a plasma cell dyscrasia and lipid metabolism disorders.