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Related Experiment Videos

T helper cells.

R Noelle1, E C Snow

  • 1Department of Microbiology, Dartmouth Medical School, Lebanon, New Hampshire 03756.

Current Opinion in Immunology
|June 1, 1992
PubMed
Summary
This summary is machine-generated.

T helper cells control B-cell growth and differentiation. A novel T-cell protein activates B cells via CD40, with cytokines like interleukin-4 and -5 driving B-cell proliferation and maturation.

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Area of Science:

  • Immunology
  • Cell Biology

Background:

  • T helper cells are crucial regulators of B-cell proliferation and differentiation.
  • B-cell activation is a key process in adaptive immunity.

Purpose of the Study:

  • To elucidate the molecular mechanisms underlying T-cell-dependent B-cell activation.
  • To identify the specific T-cell molecule and B-cell receptor involved in this interaction.

Main Methods:

  • The study focused on identifying a novel T-cell membrane protein.
  • Investigated the interaction between this T-cell protein and B-cell surface receptors.

Main Results:

  • A novel 39 kD T-cell membrane protein was identified as responsible for inducing T-cell-dependent B-cell activation.

Related Experiment Videos

  • CD40 was confirmed as the specific receptor for this T-cell protein on resting B cells.
  • Activated T cells release interleukin-4 and interleukin-5, promoting B-cell growth and differentiation.

    • Conclusions:

    • T-cell-B cell contact, mediated by a novel T-cell protein and CD40, is essential for B-cell activation.
    • Soluble factors, including interleukins, provide necessary signals for B-cell proliferation and differentiation.
    • Combined T-cell contact and soluble factors orchestrate the complete B-cell immune response.