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Kinin generation following methacholine nasal airway challenge of non-allergic subjects
C R Baumgarten1, W Niemz, G Kunkel
1Department of Clinical Immunology, Free University of Berlin, Federal Republic of Germany.
Abstract:
Following nasal challenges with the muscarinic neurotransmitter methacholine in 14 patients with chronic non-allergic rhinitis, kinin generation was induced. This occurrence was inhibited by pretreatment with anticholinergic agents (ipratropium bromide) and by an overdose of neurotransmitter, indicating that a muscarinic receptor is stimulating the liberation of kinin. These observations suggest that patients with chronic non-allergic rhinitis exhibit cholinergic neurotransmitter-induced kinin generation.