[Effect of coamide on immunogenesis during antibiotic therapy]

The dynamics of the antibody-producing cells in the spleen and the titer of hemagglutinines in the blood of albino mice immunized with sheep erythrocytes and treated with various doses (250, 500, 1000 gamma) of oxytetracycline and monomycin and their combinations with coamide, a complex of cobalt with nicotinic acid amide at different periods after the immunization. It was found that oxytetracycline in doses of 500 and 1000 gamma and monomycin in doses of 250, 500 and 1000 gamma administered intramuscularly for 4 days had an inhibitory effect on both the antibody-producing cells and the titer of hemagglutinines in the immunized animals at various periods after the immunization. Consequently, oxytetracycline and monomycin had the immunosuppressive effect. Exposure of the animals treated with oxytetracycline and monomycin to coamide for 5 days provided an increase in the number of the antibody-producing cells and the titer of the hemagglutinines. The results of the study showed the perspectivity of coamide use in complex therapy of infectious diseases.