HEMOGLOBINS A AND F: FORMATION IN THALASSEMIA AND OTHER HEMOLYTIC ANEMIAS

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Published on: August 5, 2011

P A MARKS, E R BURKA

    Science (New York, N.Y.)
    |May 1, 1964
    PubMed

    Rates of synthesis of hemoglobin A by erythroid cells from thalassemic subjects are markedly decreased. Formation of hemoglobin F, however, proceeds at similar rates in cells from subjects with thalassemia and other types of hemolytic anemias. A mechanism is suggested regarding the altered patterns of hemoglobin synthesis under conditions of erythropoietic stimulation in subjects with and without thalassemia.

    Keywords:
    CARBON ISOTOPESDNAERYTHROPOIESISHEMOGLOBINS, ABNORMALHISTOCYTOCHEMISTRYISOLEUCINELEUCINEPROTEIN METABOLISMRIBOSOMESRNATHALASSEMIA

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