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Related Experiment Videos

Virilizing adrenal cortical carcinoma.

C Nogeire, D K Fukushima, L Hellman

    Cancer
    |July 1, 1977
    PubMed
    Summary

    This case study details a man with virilization due to adrenal carcinoma, presenting precocious puberty at age 7. His 36-year course suggests a slow-growing tumor or congenital adrenal hyperplasia progression.

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    Area of Science:

    • Endocrinology
    • Oncology
    • Pediatric Endocrinology

    Background:

    • A 43-year-old male presented with a 36-year history of virilization.
    • Initial symptoms at age 7 included precocious puberty and epiphyseal bone fusion, indicating early androgen excess.

    Observation:

    • The patient's prolonged course suggested either a slow-growing adrenal carcinoma or congenital adrenal hyperplasia progressing to malignancy.
    • Endocrine evaluation revealed significantly elevated dehydroepiandrosterone (DHEA) and DHEA-sulfate levels.
    • Elevated plasma and urinary estradiol, suppressed luteinizing hormone (LH) and follicle-stimulating hormone (FSH) were noted.

    Findings:

    • Normal 24-hour mean levels of cortisol and testosterone were observed.
    • Cortisol circadian rhythm showed disturbed temporal patterns but a normal 24-hour mean concentration and production rate.
    • The 24-hour LH secretory pattern exhibited reduced episodic fluctuations.

    Implications:

    • This case highlights the complex hormonal dysregulation in long-standing virilization potentially linked to adrenal carcinoma.
    • Understanding these endocrine patterns is crucial for diagnosing and managing rare pediatric and adult endocrine disorders.
    • The findings underscore the importance of comprehensive endocrine assessment in cases of prolonged precocious puberty and virilization.

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