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ENZOOTIC SENDAI VIRUS INFECTIONS IN MOUSE BREEDER COLONIES WITHIN THE UNITED STATES

J C PARKER, R W TENNANT, T G WARD

    Science (New York, N.Y.)
    |November 13, 1964
    PubMed

    Insights

    Sendai virus, a common pathogen, was found in 29% of US mouse breeder colonies. Infected colonies showed a high average incidence of 76%, impacting research animal health.

    Area of Science:

    • Veterinary Virology
    • Animal Health Monitoring
    • Zoonotic Disease Research

    Background:

    • Sendai virus is an important respiratory pathogen in rodents.
    • Enzootic infections can impact the health and reliability of research animal models.
    • Monitoring for viral pathogens in animal colonies is crucial for research integrity.

    Purpose of the Study:

    • To determine the prevalence of Sendai virus infections in US mouse breeder colonies.
    • To assess the incidence of Sendai virus within infected colonies.
    • To report findings from serologic monitoring and virus isolation.

    Main Methods:

    • Serologic monitoring was used to detect antibodies against Sendai virus.
    • Virus isolation attempts were performed on samples from mouse colonies.
    • Data were collected from breeder colonies across five US states.

    Main Results:

    • Sendai virus infection was detected in 6 out of 21 (28.6%) mouse breeder colonies surveyed.
    • The mean incidence of infection in positive colonies was 76%.
    • Virus isolation was successful in 41 out of 120 (34.2%) attempts.

    Conclusions:

    • Sendai virus is enzootic in mouse breeder colonies in the United States.
    • The high incidence in infected colonies poses a significant risk to research animal supply.
    • Continued surveillance and control measures are necessary to mitigate the impact of Sendai virus.
    Keywords:
    COMPLEMENT FIXATION TESTSHEMAGGLUTINATION INHIBITION TESTSMICERODENT DISEASESSENDAI VIRUSUNITED STATESVIRUS DISEASES

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