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Related Experiment Videos

Some methods for evaluating clinical itch and their application for studying pathophysiological mechanisms.

O Hägermark1, C F Wahlgren

  • 1Department of Dermatology, Karolinska Hospital, Stockholm, Sweden.

Journal of Dermatological Science
|September 1, 1992
PubMed
Summary

Quantitative measurements of clinical itch using a novel microcomputer system revealed that antihistamines do not treat atopic dermatitis itch. Cyclosporin A, a cytokine inhibitor, effectively reduced itch, suggesting cytokines, not histamine, are key itch triggers.

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Area of Science:

  • Dermatology
  • Clinical pharmacology
  • Neuroscience

Background:

  • Measuring itch sensation in clinical research has been challenging.
  • Atopic dermatitis is a common skin condition characterized by intense itching.
  • The role of histamine and cytokines in mediating itch in atopic dermatitis is not fully understood.

Purpose of the Study:

  • To introduce a microcomputer-based system for quantitative measurement of clinical itch.
  • To evaluate the antipruritic effects of antihistamines and cyclosporin A in atopic dermatitis.
  • To investigate the role of histamine and cytokines in the pathophysiology of itch in atopic dermatitis.

Main Methods:

  • Development and utilization of a patient-operated, microcomputer-based system for symptom recording.

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  • Portable data loggers were used by patients to quantify their itch symptoms.
  • Assessment of drug efficacy by measuring changes in self-reported itch intensity.

    • Main Results:

    • The microcomputer system enabled quantitative measurements of clinical itch.
    • Antihistamines did not show significant antipruritic effects in patients with atopic dermatitis.
    • Cyclosporin A, a drug that inhibits cytokine production, effectively reduced itch in atopic dermatitis.

    Conclusions:

    • Histamine is likely not a major pruritogen (itch-inducing substance) in atopic dermatitis.
    • Cytokines are implicated as key mediators of itch in atopic dermatitis.
    • The developed microcomputer system is a valuable tool for assessing antipruritic drug effects.